Dopamine in the ventral tegmental area facilitates emergence from general anesthesia
نویسندگان
چکیده
منابع مشابه
Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia.
Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emotion, reinforcement, and cognition, but their role in regulating wakefulness is ...
متن کاملSalsolinol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Posterior Ventral Tegmental Area of Rats
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated. We have reported previously that salsolinol stimulates dopamine neurons in the posterior ventral tegmental area (p-VTA) partly by reducing inhibitory GABAergic transmission, and ...
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BACKGROUND Methylphenidate or a D1 dopamine receptor agonist induces reanimation (active emergence) from general anesthesia. The authors tested whether electrical stimulation of dopaminergic nuclei also induces reanimation from general anesthesia. METHODS In adult rats, a bipolar insulated stainless steel electrode was placed in the ventral tegmental area (VTA, n = 5) or substantia nigra (n =...
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Midbrain dopaminergic (DA) neurons signal motivational properties of natural reinforces and addictive drugs. Nicotine, like other drugs of abuse, boosts DA output from the ventral tegmental area (VTA). This increase results from direct stimulation of nicotinic acetylcholine receptors (nAChRs) expressed in the VTA. However, how the DA signal is constructed in the VTA and how nicotine changes thi...
متن کاملCharacterization of M-current in ventral tegmental area dopamine neurons.
M-current (I(M)) is a voltage-gated potassium current (KCNQ type) that affects neuronal excitability and is modulated by some drugs of abuse. Ventral tegmental area (VTA) dopamine (DA) neurons are important for the reinforcing effects of drugs of abuse. Therefore we studied I(M) in acutely dissociated rat DA VTA neurons with nystatin-perforated patch recording. The standard deactivation protoco...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2017
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2017.01.61